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KMID : 0381120150370030287
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Genes and Genomics
2015 Volume.37 No. 3 p.287 ~ p.294
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HExDB: a database for epigenetic changes occurring after horse exercise
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Gim Jeong-An
Lee Su-Gi
Kim Dae-Soo
Jeong Kwang-Seuk
Hong Chang-Pyo
Bae Jin-Han
Moon Jae-Woo
Choi Yong-Seok
Cho Byung-Wook
Cho Hwan-Gue
Bhak Jong
Kim Heui-Soo
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Abstract
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DNA methylation is an essential biochemical modification that regulates gene expression. Exercise induces changes in gene expression that adapt as metabolic changes in the blood. We provide a database for the epigenetic changes after horse exercise (http://www.primate.or.kr/hexdb). Horse Exercise Epigenetic Database (HExDB) explicates the change in genome-wide DNA methylation patterns after exercise. Exercise changes the genome-wide epigenetic patterns, and understanding the regions that change is important for confirming exercise physiological mechanisms. For this purpose, our database provides information on differentially methylated regions after exercise that pass a set threshold. A total of 784 genes based on NCBI RefSeq were identified as differentially methylated in equines after exercise. Our database provides clues for the study of exercise-related epigenetic pathways in the thoroughbred horse.
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KEYWORD
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Thoroughbred horse, Exercise, Differentially methylated region, Transposable element, MeDIP-Seq
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